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La cellule musculaire lisse vasculaire (CMLV)

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  • Feng J, Ito M, Ichikawa K, Isaka N, Nishikawa M, Hartshorne DJ, Nakano T (1999) Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. J Biol Chem 274:37385-90.
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  • Ikebe M, Hartshorne DJ (1985) Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase. J Biol Chem 260:10027-10031.
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  • James P, Inui M, Tada M, Chiesi M, Carafoli E (1989) Nature and site of phospholamban regulation of the Ca2+ pump of sarcoplasmic reticulum. Nature 342:90-92.


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  • Komalavilas P, Lincoln TM (1994) Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase. J Biol Chem 269:8701-8707.
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  • Kwan CY (1982) Mg2+- or Ca2+-activated ATPase activities of plasma membranes isolated from vascular smooth muscle. Enzyme 28:317-327.
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  • Lands AM, Arnold A, McAuliff JP, Luduena FP, Brown TG Jr (1967) Differentiation of receptor systems activated by sympathomimetic amines. Nature 214:597-598.
  • Lincoln TM, Dey N, Sellak H (2001) Sep. Invited review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression. J Appl Physiol 91:1421-30.
  • Lorenz JN, Bielefeld DR, Sperelakis N (1994) Regulation of calcium channel current in A7r5 vascular smooth muscle cells by cyclic nucleotides. Am J Physiol 266:C1656-C1663.
  • Lytton J, MacLennan DH (1988) Molecular cloning of a cDNA from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene. J Biol Chem 263 : 15024-15031.
  • Lytton J, Zarain-Hertzberg A, Periasamy M, MacLennan DH (1989) Molecular cloning of the mammalian smooth muscle sarco(endo)plasmic reticulum Ca2+-ATPase. J Biol Chem 264 : 7059-7065.


  • Marin J (1993) Mechanisms involved in the increased vascular resistance in hypertension. J Auton Pharmacol 13:127-176.
  • McDonald TF, Pelzer S, Trautwein W, Pelzer DJ (1994) Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol Rev 74:365-507.
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  • Orallo F (1996) Regulation of cytosolic calcium levels in vascular smooth muscle. Pharmacol Ther 69:153-71.
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  • Pelzer D, Pelzer S, McDonald TF (1990) Properties and regulation of calcium channels in muscle cells. Rev Physiol Biochem Pharmacol 114:107-207.
  • Pfitzer G (2001) Invited review: regulation of myosin phosphorylation in smooth muscle. J Appl Physiol 91:497-503.
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  • Tansey MG, Luby-Phelps K, Kamm KE, Stull JT (1994) Ca(2+)-dependent phosphorylation of myosin light chain kinase decreases the Ca2+ sensitivity of light chain phosphorylation within smooth muscle cells. J Biol Chem 269:9912-20.
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  • Watterson DM, Sharief F, Vanaman TC (1980) The complete amino acid sequence of the Ca2+-dependent modulator protein (calmodulin) of bovine brain. J Biol Chem 255:962-975.
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  • Wu X, Haystead TA, Nakamoto RK, Somlyo AV, Somlyo AP (1998) Acceleration of myosin light chain dephosphorylation and relaxation of smooth muscle by telokin. Synergisms with cyclic nucleotidde-activated kinase. J Biol Chem 273:11362-11369.


  • Zarain-Herzberg A, MacLennan DH, Periasamy M (1990) Characterisation of rabbit cardiac sarco(endo)plasmic reticulum Ca2+-ATPase gene. J Biol Chem 265 : 4670-4677.

A- Localisation, structure et fonction des CMLV
B- Mécanisme de la relaxation/contraction de la CMLV
C- Régulation de la contraction/relaxation de la CMLV


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Stéphane Frayon, Carine Cueille, Roger Prat et Jean-Michel Garel
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